Skeptical? Good. We love that.
Xylitol has been studied for more than 40 years and the research is remarkably consistent: when used 3–5 times a day (about 6g total), xylitol can dramatically reduce your cavity risk.
Here’s what the science shows:
Xylitol Gum Can Significantly Reduce Cavities
40-month, 1,135-child study
Children who chewed xylitol gum had the biggest drop in new cavities compared to sucrose, sorbitol, or mixed sweeteners.
Researchers concluded that a xylitol-based gum program can substantially reduce caries risk.
Source: Makinen KK, Bennett CA, Hujoel PP, Isokangas PJ, Isotupa KP, Pape HR Jr, Makinen KK. Xylitol chewing gums and caries rates: a 40-month cohort study. J Dent Res 1995 Dec;74(12):1904-13.
Xylitol Toothpaste Reduces Cavity-Causing Bacteria
6-month clinical trial of 155 adults
Participants using toothpaste with 10% xylitol had an 18% decrease in mutans streptococci (the bacteria responsible for many cavities).
The fluoride-only group saw almost a 10% increase in the same bacteria.
Researchers concluded that adding xylitol significantly reduces harmful bacteria in saliva and plaque.
Source: L. Jannessona, et.al, Effect of a triclosan-containing toothpaste supplemented with 10% xylitol on mutans streptococci in saliva and dental plaque. A 6-month clinical study. Caries Res. 2002 Jan-Feb;36(1):36-9.
Xylitol Gum Can Help Stop Active Decay
Two 24-month studies of 510 children
Children who chewed high-xylitol gum regularly experienced arrested or significantly slowed dentine decay, while the control groups continued to see progression.
Researchers concluded that high-xylitol gum can halt or reverse active dentine lesions.
Makinen KK, Makinen PL, Pape HR Jr, Allen P, Bennett CA, Isokangas PJ, Isotupa KP. Stabilisation of rampant caries: polyol gums and arrest of dentine caries in two long-term cohort studies in young subjects. Int Dent J 1995 Feb;45(1 Suppl 1):93-107. PMID 7607749
Why This Matters for You
Across decades of research, xylitol has consistently been shown to:
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Reduce cavity-causing bacteria
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Lower acid levels after meals
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Help enamel stay stronger
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Support a balanced oral pH
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Protect both kids and adults
And all studies align with the same effective daily dose: about 6g of xylitol (3–5 uses per day).
Epic just makes it easy and enjoyable to get the amount that works.
Try It Yourself With Zero Risk
Dentists recommend xylitol.
Customers swear by it.
And we guarantee you’ll feel the difference.
Take the Epic 6-Month Challenge and see what your next dental visit looks like.
Still have questions? We're happy to help.
Other Studies Show Xylitol's Benefits
If you prefer to do more research on your own, below is list of additional studies about xylitol, xylitol side effects, and its potential tooth-protecting benefits:
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Laitala ML, Alanen P, Isokangas P, Söderling E, Pienihäkkinen K. Long-term effects of maternal prevention on children's dental decay and need for restorative treatment. Community Dent Oral Epidemiol. 2013 Dec;41(6):534-40. doi: 10.1111/cdoe.12057. Epub 2013 Jun 20.
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Mäkinen KK, Järvinen KL, Anttila CH, Luntamo LM, Vahlberg T. Topical xylitol administration by parents for the promotion of oral health in infants: a caries prevention experiment at a Finnish Public Health Centre. Int Dent J. 2013 Aug;63(4):210-24. doi: 10.1111/idj.12038. Epub 2013 Apr 15.
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Campus G, Cagetti MG, Sale S, Petruzzi M, Solinas G, Strohmenger L, Lingström P. Six months of high-dose xylitol in high-risk caries subjects--a 2-year randomised, clinical trial.Clin Oral Investig. 2013 Apr;17(3):785-91. doi: 10.1007/s00784-012-0774-5. Epub 2012 Jul 13.
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Shinga-Ishihara C, Nakai Y, Milgrom P, Söderling E, Tolvanen M, Murakami K. Xylitol carryover effects on salivary mutans streptococci after 13 months of chewing xylitol gum. Caries Res. 2012;46(6):519-22. doi: 10.1159/000341221. Epub 2012 Aug 10.
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Milgrom P, Söderling EM, Nelson S, Chi DL, Nakai Y. Clinical evidence for polyol efficacy. Adv Dent Res. 2012 Sep;24(2):112-6. doi: 10.1177/0022034512449467.
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Subramaniam P, Nandan N. Effect of xylitol, sodium fluoride and triclosan containing mouth rinse on Streptococcus mutans. Contemp Clin Dent. 2011 Oct;2(4):287-90. doi: 10.4103/0976-237X.91790.
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Seki M, Karakama F, Kawato T, Tanaka H, Saeki Y, Yamashita Y. Effect of xylitol gum on the level of oral mutans streptococci of preschoolers: block-randomised trial. Int Dent J. 2011 Oct;61(5):274-80. doi: 10.1111/j.1875-595X.2011.00073.x.
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Campus G, Cagetti MG, Sacco G, Solinas G, Mastroberardino S, Lingström P. Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci. Caries Res. 2009;43(6):455-61. doi: 10.1159/000264682. Epub 2009 Dec 10.
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Edelstein BL. Xylitol syrup can reduce dental caries progression in young children. J Pediatr. 2010 Jan;156(1):164. doi: 10.1016/j.jpeds.2009.09.058.
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Milgrom P. Xylitol-containing oral syrup may prevent caries in children. J Am Dent Assoc. 2009 Aug;140(8):972.
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Milgrom P, Ly KA, Tut OK, Mancl L, Roberts MC, Briand K, Gancio MJ. Xylitol pediatric topical oral syrup to prevent dental caries: a double-blind randomized clinical trial of efficacy. Arch Pediatr Adolesc Med. 2009 Jul;163(7):601-7. doi: 10.1001/archpediatrics.2009.77.
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Splieth CH, Alkilzy M, Schmitt J, Berndt C, Welk A. Effect of xylitol and sorbitol on plaque acidogenesis. Quintessence Int. 2009 Apr;40(4):279-85.
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Deshpande A, Jadad AR. The impact of polyol-containing chewing gums on dental caries: a systematic review of original randomized controlled trials and observational studies. J Am Dent Assoc. 2008 Dec;139(12):1602-14.
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Milgrom P, Ly KA, Roberts MC, Rothen M, Mueller G, Yamaguchi DK. Mutans streptococci dose response to xylitol chewing gum. J Dent Res. 2006 Feb;85(2):177-81.
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Holgerson PL, Sjöström I, Stecksén-Blicks C, Twetman S. Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. Int J Paediatr Dent. 2007 Mar;17(2):79-85.
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Aguirre-Zero O, Zero DT, Proskin HM. Evaluation of the dental plaque pH recovery effect of a xylitol lozenge on patients with fixed orthodontic appliances. Angle Orthod. 2004 Apr;74(2):240-4.
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Isokangas P, Söderling E, Pienihäkkinen K, Alanen P. Occurrence of dental decay in children after maternal consumption of xylitol chewing gum, a follow-up from 0 to 5 years of age. J Dent Res. 2000 Nov;79(11):1885-9.
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Hildebrandt GH, Sparks BS. Maintaining mutans streptococci suppression with xylitol chewing gum. J Am Dent Assoc. 2000 Jul;131(7):909-16.
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Mäkinen KK, Hujoel PP, Bennett CA, Isokangas P, Isotupa K, Pape HR Jr, Mäkinen PL. A descriptive report of the effects of a 16-month xylitol chewing-gum programme subsequent to a 40-month sucrose gum programme. Caries Res. 1998;32(2):107-12.
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Mäkinen KK, Hujoel PP, Bennett CA, Isotupa KP, Mäkinen PL, Allen P. Polyol chewing gums and caries rates in primary dentition: a 24-month cohort study. Caries Res. 1996;30(6):408-17.